North Central London
Joint Formulary
 
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5 Infections

Prescribing of systemic antimicrobials is 'protected'. All prescribing MUST be in accordance with the Trust Antimicrobial Policy and in conjunction with local antimicrobial guideline:

05-01-09 Antituberculosis drugs

Bedaquiline
Formulary

Approved for XDR-TB and MDR-TB in line with the NHS England Clinical Commissioning Policy F04/P/a (JFC April 2017)

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Approved for XDR-TB and MDR-TB in line with NHSE policy
    • Restricted to ID team only
  • RNOH:
    • Non-formulary  
  • UCLH:
    • Pulmonary multidrug-resistant tuberculosis in line with NHS England policy, restricted to TB team
  • WH:
    • As above
Link  NHSE 170132P: Treatment for defined patients with MDR-TB and XDR-TB including bedaquiline and delamanid

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Capreomycin
Restricted

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • Microbiology/ ID approval only (TB treatment)
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Restricted to TB clinic or as per Microbiology advice

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Cycloserine
Restricted

Provider notes

  • NMUH:
    • Restricted for the use in combination with other drugs for Tuberculosis resistant to first line drugs only
  • RFL:
    • Microbiology/ ID approval only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • Restricted to TB clinic or as per Microbiology advice

Restricted Drug View adult BNF  View SPC online  View childrens BNF
Delamanid
Restricted

Approved for XDR-TB and MDR-TB in line with the NHS England Clinical Commissioning Policy F04/P/a (JFC April 2017)

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • As per NHSE policy for XDR-TB and MDR-TB
  • RNOH:
    • Non-formulary  
  • UCLH:
    • Pulmonary multidrug-resistant tuberculosis in line with NHS England policy, restricted to TB team
  • WH:
    • TB clinic only
Link  NHSE 170132P: Treatment for defined patients with MDR-TB and XDR-TB including bedaquiline and delamanid

Restricted Drug GP - Red View adult BNF  View SPC online  View childrens BNF  HCD
Ethambutol
Restricted

Provider notes

  • NMUH:
    • No restriction stated (suspension 400mg/5ml [unlicensed] is available for the treatment of tuberculosis in children)
  • RFL:
    • For treatment of tuberculosis only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • No restriction stated

Restricted Drug View adult BNF  View SPC online  View childrens BNF
Isoniazid
Restricted

Provider notes

  • NMUH:
    • No restriction stated (Isoniazid elixir 50mg/5mL [unlicensed] available for the treatment of tuberculosis in children)
  • RFL:
    • For treatment and prophylaxis of tuberculosis only
    • Microbiology or ID approval required for other indications
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • No restriction stated

Restricted Drug View adult BNF  View SPC online  View childrens BNF
Pyrazinamide
Restricted

Provider notes

  • NMUH:
    • No restriction stated (pyrazinamide 500mg/5mL suspension [unlicensed] available for the treatment of tuberculosis in children)
  • RFL:
    • For treatment of tuberculosis only  
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • No restriction stated

Restricted Drug View adult BNF  View SPC online  View childrens BNF
Rifabutin
Restricted

Provider notes

  • NMUH:
    • Restricted to AIDS patients use only
  • RFL:
    • For HIV / TB Consultant use only
  • RNOH:
    • Non-formulary  
  • UCLH:
  • WH:
    • For HIV / TB Consultant use only

Restricted Drug View adult BNF  View SPC online  View childrens BNF
Rifampicin
Restricted

NOTE: There is more than one monograph for this medicine, click here to search for formulary status and its use for other indications. 

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • For treatment of tuberculosis only
    • Microbiology/ID approval required for all other indications
  • RNOH:
    • No restriction stated
  • UCLH:
  • WH:
    • Microbiology approval only

Restricted Drug View adult BNF  View SPC online  View childrens BNF
Rifampicin + Isoniazid Rifinah® 150 & 300
Restricted

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • For treatment of tuberculosis only
    • Microbiology/ID approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • No restriction stated

Restricted Drug View adult BNF  View SPC online  View childrens BNF
Rifampicin + Isoniazid + Pyrazinamide Rifater®
Restricted

Provider notes

  • NMUH:
    • No restriction stated
  • RFL:
    • For treatment of tuberculosis only
    • Microbiology/ID approval only
  • RNOH:
    • Microbiologist approval only
  • UCLH:
  • WH:
    • TB / Microbiology approval only

Restricted Drug View adult BNF  View SPC online  View childrens BNF
Rifampicin + Isoniazid + Pyrazinamide + Ethambutol Voractiv®
Formulary

Provider notes

  • NMUH:
    • Non-formulary
  • RFL:
    • For treatment of tuberculosis only
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary

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Aminosalicylic acid
Formulary

Provider notes

  • NMUH:
    • Available from 'special order' manufacturers
  • RFL:
    • Available from 'special order' manufacturers
    • MDR-TB only
    • Restricted to ID / Microbiology
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary

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Protionamide
Formulary

Provider notes

  • NMUH:
    • For Multidrug resistent TB
    • To be prescribed by Respiratory Consultants ONLY
    • Protionamide 250mg tablets, Available from ‘special-order’ manufacturers or specialist importing companies
  • RFL:
    • Available from 'special order' manufacturers
    • MDR-TB only
    • Restricted to ID / Microbiology
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • For specialist use only

View adult BNF  View SPC online  View childrens BNF
Terizidone
Non Formulary

Approved for treatment of TB, if cycloserine is unavailable (JFC August 2020).

Provider notes

  • NMUH:
    • Treatment of TB, if cycloserine is unavailable
  • RFL:
    • Non-formulary
  • RNOH:
    • Non-formulary
  • UCLH:
  • WH:
    • Non-formulary

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